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. 1997 Oct;17(10):614-5.

[Effect of allitridi on expression of proliferating cell nuclear antigen of cultured rabbit aortic smooth muscle cell]

[Article in Chinese]
Z C Li  1 , G S Li, C X Huang
Affiliations
  • PMID: 10322894

[Effect of allitridi on expression of proliferating cell nuclear antigen of cultured rabbit aortic smooth muscle cell]

[Article in Chinese]
Z C Li et al. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Oct.

Abstract

Objective: To observe the effect of allitridi on the expression of proliferating cell nuclear antigen (PCNA) of cultured rabbit aortic smooth muscle cell (SMC).

Methods: The expression of PCNA was examined with immunohistochemical technique (LSAB method) and the contents of superoxide dismutase (SOD), lipid peroxide (LPO), prostacyclin (PGI2) and cyclic adenosine monophosphate (cAMP) in medium were simultaneously determined.

Results: Allitridi has the effects of increasing SOD activity, decreasing LPO, elevating PGI2 and cAMP, reducing the expression of PCNA (all P < 0.05-0.01).

Conclusion: Allitridi could inhibit SMC proliferation.

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