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. 1999 Mar;5(3):155-8.
doi: 10.1002/(SICI)1099-1387(199903)5:3<155::AID-PSC195>3.0.CO;2-E.

Benzotriazonine as a new core structure for the design of CCK-receptor antagonists

A Escherich  1 , C Escrieut, D Fourmy, L Moroder
Affiliations

Benzotriazonine as a new core structure for the design of CCK-receptor antagonists

A Escherich et al. J Pept Sci. 1999 Mar.

Abstract

The search for heterocyclic scaffolds for the design of non-peptidic and highly selective agonists or antagonists of peptide hormone receptors led to 4-N-benzyl-2,3,4,5,6,7-hexahydro-1H-1,4,7-benzotriazonin-2, 6-dione with a 9-membered core structure as a new low mass lead compound that exhibits submicromolar antagonistic activity at the CCK-A receptor with a 54-fold selectivity over the CCK-B/gastrin receptor.

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