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. 1999 Apr;126(7):1534-6.
doi: 10.1038/sj.bjp.0702468.

Functional evidence of alpha1D-adrenoceptors in the vasculature of young and adult spontaneously hypertensive rats

R Villalobos-Molina  1 , J J López-Guerrero, M Ibarra
Affiliations

Functional evidence of alpha1D-adrenoceptors in the vasculature of young and adult spontaneously hypertensive rats

R Villalobos-Molina et al. Br J Pharmacol. 1999 Apr.

Abstract

The role of alpha1D-adrenoceptors in the vasculature of spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY), of different ages was assessed in pithed rats by the use of the selective alpha1D-adrenoceptor antagonist BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-8-azaspiro [4.5]decane-7,9-dione dihydrochloride). BMY 7378 displaced the pressor effect of phenylephrine in young pre-hypertensive pithed SHR rats, but produced no effect in young WKY rats (dose ratio of 3.4 and 1.6, respectively), while in adult rats BMY 7378 produced a greater shift in the phenylephrine response curve than in younger animals (dose ratio of 3.2 and 6.2 in WKY and SHR, respectively). The presence of alpha1D-adrenoceptors in the vasculature of pre-hypertensive rats, suggests its role in the pathogenesis/maintenance of increased blood pressure.

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Figures

Figure 1
Figure 1
Antagonist action of BMY 7378 in the pressor response to phenylephrine in WKY and SHR rats of different age. Pithed rats of 1 and 6 months of age were subjected to increasing i.v. doses of phenylephrine. (A) WKY, 1 month; (B) WKY, 6 months; (C) SHR, 1 month; (D) SHR, 6 months. Points represent the mean±s.e.mean of 3–7 rats.
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