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Review
. 1999 Apr;10(2):143-50.
doi: 10.1097/00041433-199904000-00008.

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

J D Horton  1 , I Shimomura
Affiliations
Review

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

J D Horton et al. Curr Opin Lipidol. 1999 Apr.

Abstract

A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.

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