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. 1999 Apr 19;9(8):1167-70.
doi: 10.1016/s0960-894x(99)00158-4.

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

J S Carter  1 , D J Rogier, M J Graneto, K Seibert, C M Koboldt, Y Zhang, J J Talley
Affiliations

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

J S Carter et al. Bioorg Med Chem Lett. .

Abstract

A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

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