Antibodies to spermatozoa. VII humoral and cellular aspects of sperm inmunity and infertility

Abstract

The occurrence of sperm antibody in serum and cervical mucus of women from intertile couples in the serum of their male partners, as well as cellular immunity to sperm, has been studied by agglutination and immobilization techniques. For a total of about 260 couples, the tests on serum showed that 18% of the women and 8% of the men were positive by the Kibrick technique and that 15% of the women and 4% of the men were positive by the F-D technique. The women who were positive in their cervical mucus were 8% of the group by the K-agg (Kibrick agglutination) technique, 2% by the MIS-agg. (Microscale agglutination) technique, and 40% by the MIS-imm. (Microscale immobilization) tecnique. In considering all three techniques. 42% of a group of 132 women were positive. Cellular immunity to sperm, by the Migration Inhibition method, was positive in 18% and zero per cent of infertile and fertile women, respectively.

PIP: 2 methods of sperm agglutination techniques, the Kibrick method and the F-D method, were used to evaluate 260 infertile couples. The test material consisted of an extract of cervical mucus. 18% of the women and 8% of the men were positive by the Kibrick technique. 15% of the women and 4% of the men were positive by the F-D technique. 8% of the women were positive in their cervical mucus by the Kibrick agglutination method, 2% by the Microscale agglutination method, and 40% by the microscale immobilization method. Cellular immunity to sperm by the migration inhibition method was 18% in infertile women and 0% in fertile women. This method is less certain than antibody immunity methods.