[Pharmacological studies on bamboo grass. (2) Central depressant and antitoxic actions of a water-soluble fraction (folin) extracted from Sasa albomarginata Makino et Shibata]

Abstract

Folin administered showed a significant antagonistic effect to caffeine induced hyperactivity and slightly prolonged hexobarbital induced sleeping time in mice. An antitussive effect was evident only with high doses and anticonvulsant effects were not observed. A mixture of Folin with HgCl2, NaAsO2, 3CdSO4-8H2O or tetrodotoxin resulted in an apparent decrease in mortality rates. However Folin had no effect in the case of alternate administration with a poison or preadministration of Folin. As other pharmacological properties of Folin, a protective effect on induced stress ulcer in rats and an increase in acid output in pylorus-ligated rats in which aspirin was administered. Folin had no inhibitory effect on reserpine ulcer and acetic acid induced anal ulcer in the rat. Neither an increase in gastric motility nor cathartic effect was observed with Folin. In addition, Folin showed a tendency of inhibition on heat induced edema and increase of urinary vikyne and electrolytes in rats.