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. 1999 May 12;52(8):1687-9.
doi: 10.1212/wnl.52.8.1687.

Correlation between rates of brain atrophy and cognitive decline in AD

N C Fox  1 , R I Scahill, W R Crum, M N Rossor
Affiliations

Correlation between rates of brain atrophy and cognitive decline in AD

N C Fox et al. Neurology. .

Abstract

Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of serial scans. Rate of global cerebral volume loss correlated strongly with rate of change in Mini-Mental State Examination scores (r = 0.80, p < 0.001), implying clinical relevance to this marker of progression.

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