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. 1999 May 12;52(8):1701-4.
doi: 10.1212/wnl.52.8.1701.

IgM antibody-related polyneuropathies: B-cell depletion chemotherapy using Rituximab

T D Levine  1 , A Pestronk
Affiliations

IgM antibody-related polyneuropathies: B-cell depletion chemotherapy using Rituximab

T D Levine et al. Neurology. .

Abstract

Current treatments for anti-GM1 ganglioside or antimyelin-associated glycoprotein (anti-MAG) antibody-associated polyneuropathies are toxic or very costly. In this preliminary study the authors treated five patients with neuropathy and immunoglobulin M antibodies to GM1 ganglioside or MAG by depleting B cells using Rituximab--a monoclonal antibody directed against the B-cell surface membrane marker CD20. Within 3 to 6 months after treatment, all five patients had improved function, significantly increased quantitative strength measurements, and reduced titers of serum autoantibodies.

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