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. 1999;48(2):108-10.
doi: 10.1002/(sici)1097-4636(1999)48:2<108::aid-jbm2>3.0.co;2-f.

Cell culture test of TCP/CPLA composite

M Kikuchi  1 , J Tanaka, Y Koyama, K Takakuda
Affiliations

Cell culture test of TCP/CPLA composite

M Kikuchi et al. J Biomed Mater Res. 1999.

Abstract

Thermoplastic polymers filled with a ceramic powder (here described as a "composite") of beta-tricalcium phosphate (TCP) and copoly-L-lactide (CPLA) was prepared by a heat-kneading method. The TCP/CPLA composite obtained had a three-point bending strength of 51.26 +/- 634 MPa, a Young's modulus of 5.18 +/- 1.11 GPa, and a fracture strength of 52.64 +/- 2.975 MPa, which is sufficient for usage as an artificial bone implant material. According to cell culture tests using MC3T3-E1 cells, the TCP/CPLA composite showed no cytotoxicity and the cells were in close contact with the surfaces of the composite without any observable morphological change. These results suggest that a composite consisting of osteoconductive TCP and biodegradable CPLA is suitable as a bioactive artificial bone material.

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