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Clinical Trial
. 1999 May;158(5):414-5.
doi: 10.1007/s004310051104.

Comparison of albumin versus bicarbonate treatment for neonatal metabolic acidosis

Affiliations
Clinical Trial

Comparison of albumin versus bicarbonate treatment for neonatal metabolic acidosis

H Dixon et al. Eur J Pediatr. 1999 May.

Abstract

In this study the effectiveness of 4.5% human albumin was compared with 4.2% sodium bicarbonate for neonatal metabolic acidosis, using a randomised controlled trial. The change in median pH following bicarbonate was more than twice that in the albumin group. This was statistically significant.

Conclusion: In normotensive infants, use of bicarbonate to correct metabolic acidosis may be more effective than use of albumin.

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