Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976;5(1):81-90.
doi: 10.1002/jss.400050109.

The action of cytochalasin A on the in vitro polymerization of brain tubulin and muscle G-actin

R H Himes, L L Houston

The action of cytochalasin A on the in vitro polymerization of brain tubulin and muscle G-actin

R H Himes et al. J Supramol Struct. 1976.

Abstract

The presence of cytochalasin A inhibits the self-assembly of beef brain tubulin and rabbit muscle G-actin in vitro and also decreases the colchicine binding of tubulin. Prior reaction of cytochalasin A with 2-mercaptoethanol destroys its inhibitory effects. It is shown that cytochalasin A exerts its actions by reacting with sulfhydryl groups, possibly causing irreversible structural changes in the proteins. Cytochalasin B does not affect the tubulin assembly reaction.

PubMed Disclaimer

Publication types