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Review
. 1999 May 21;284(5418):1328-33.
doi: 10.1126/science.284.5418.1328.

Helicobacter pylori virulence and genetic geography

A Covacci  1 , J L Telford, G Del Giudice, J Parsonnet, R Rappuoli
Affiliations
Review

Helicobacter pylori virulence and genetic geography

A Covacci et al. Science. .

Abstract

Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.

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