Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Mar;122(3):327-30.
doi: 10.1016/s0742-8413(98)10136-6.

Inhibition of sea urchin fertilization by fatty acid ethanolamides and cannabinoids

E V Berdyshev  1
Affiliations

Inhibition of sea urchin fertilization by fatty acid ethanolamides and cannabinoids

E V Berdyshev. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Mar.

Abstract

The influence of saturated and unsaturated fatty acid ethanolamides as well as delta9-tetrahydrocannabinol (delta9-THC), WIN 55,212-2 and cannabinoid CB1 receptor antagonist SR 141716 on sea urchin fertilization was studied. The ethanolamides of arachidonic, oleic and linoleic acids but not saturated fatty acid (C14-C20) derivatives inhibited fertilization when pre-incubated with sperm cells. Delta9-THC and WIN 55,212-2 also inhibited fertilization, delta9-THC being ten times as potent as WIN 55,212-2. Selective cannabinoid CB1 receptor antagonist SR 141716 also blocked fertilization and did not antagonize the action of delta9-THC. The obtained results indicate that different unsaturated fatty acid ethanolamides may control sea urchin fertilization, and that sea urchin sperm cell cannabinoid receptor may differ from the known cannabinoid receptor subtypes.

PubMed Disclaimer

LinkOut - more resources