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. 1999 May;14(5):267-73.
doi: 10.1046/j.1525-1497.1999.00334.x.

Adherence to combination antiretroviral therapies in HIV patients of low health literacy

S C Kalichman  1 , B Ramachandran, S Catz
Affiliations

Adherence to combination antiretroviral therapies in HIV patients of low health literacy

S C Kalichman et al. J Gen Intern Med. 1999 May.

Abstract

Objective: To test the significance of health literacy relative to other predictors of adherence to treatment for HIV and AIDS.

Participants: Community sample of HIV-seropositive men (n = 138) and women (n = 44) currently taking a triple-drug combination of antiretroviral therapies for HIV infection; 60% were ethnic minorities, and 73% had been diagnosed with AIDS.

Measurements: An adapted form of the Test of Health Literacy in Adults (TOFHLA), a comprehensive health and treatment interview that included 2-day recall of treatment adherence and reasons for nonadherence, and measures of substance abuse, social support, emotional distress, and attitudes toward primary care providers.

Main results: Multiple logistic regression showed that education and health literacy were significant and independent predictors of 2-day treatment adherence after controlling for age, ethnicity, income, HIV symptoms, substance abuse, social support, emotional distress, and attitudes toward primary care providers. Persons of low literacy were more likely to miss treatment doses because of confusion, depression, and desire to cleanse their body than were participants with higher health literacy.

Conclusions: Interventions are needed to help persons of low literacy adhere to antiretroviral therapies.

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Figures

FIGURE 1
FIGURE 1
Barriers to antiretroviral treatment adherence in the past 30 days for persons of lower and higher literacy; significant differences indicated by +p < .06, *p < .05, **p < .01.
See this image and copyright information in PMC

Comment in

References

    1. Ho DD. Therapy of HIV infections: problems and prospects. Bull NY Acad Med. 1996;73:37–45. - PMC - PubMed
    1. Mehta S, Moore RD, Graham NMH. Potential factors affecting adherence with HIV therapy. AIDS. 1997;11:1665–70. - PubMed
    1. Samet JH, Libman H, Steger KA, et al. Compliance with zidovudine therapy in patients infected with human immunodeficiency virus, type-1: a cross-sections study in a municipal hospital clinic. Am J Med. 1992;92:495–502. - PubMed
    1. Aversa SL, Kimberlin C. Psychosocial aspects of antiretroviral medication use among HIV patients. Patient Educ Couns. 1996;29:207–19. - PubMed
    1. Morse EV, Simon PM, Coburn M, Hyslop N, Greenspan D, Balson PM. Determinants of subject compliance within an experimental anti-HIV drug protocol. Soc Sci Med. 1991;32:1161–7. - PubMed

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