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Case Reports
. 1999 May;23(9):959-62.
doi: 10.1038/sj.bmt.1701732.

Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation

R E Steg  1 , A Kessinger, Z K Wszolek
Affiliations
Case Reports

Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation

R E Steg et al. Bone Marrow Transplant. 1999 May.

Abstract

A 54-year-old woman with a myelodysplastic syndrome treated with high-dose chemotherapy and an allogenic bone marrow transplant developed acute cortical blindness while receiving tacrolimus (FK506). MRI showed white matter abnormalities. After discontinuation of FK506, the patient's vision returned within 8 days. FK506 neurotoxicity is similar to cyclosporine neurotoxicity and can occur in allogenic bone marrow transplant patients treated with FK506.

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