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. 1976 Sep;3(1):55-64.
doi: 10.1007/BF00357209.

Stabilization of double-stranded DNA molecule by non-histone peptidic effector from calf thymus

G L Gianfranceschi, D Amici, L Guglielmi

Stabilization of double-stranded DNA molecule by non-histone peptidic effector from calf thymus

G L Gianfranceschi et al. Mol Biol Rep. 1976 Sep.

Abstract

A peptidic effector from calf thymus causes a strong stabilization of DNA double-stranded molecule in vitro. The active factor was isolated from aqueous ultrafiltered thymus extracts and purified by means of chromatography on DEAE-cellulose and then on Dowex 50 WX2. The purified thymic factor was characterized as a peptide of low molecular weight (less than 5000). The biological activity of the thymic factor cannot be attributed to a histone fragment. Melting data of the control DNA and of the DNA-active factor complex in various conditions of ionic strength and dielectric constant of the solution medium are recorded.

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