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. 1976 Sep;294(3):293-5.
doi: 10.1007/BF00508398.

Porcine pituitary peptides with opiate-like activity: partial purification and effects in the rat after intraventricular injection

H Teschemacher, J Bläsig, W Kromer

Porcine pituitary peptides with opiate-like activity: partial purification and effects in the rat after intraventricular injection

H Teschemacher et al. Naunyn Schmiedebergs Arch Pharmacol. 1976 Sep.

Abstract

A peptide material with opiate-like activity in the guinea-pig ileum was extracted from porcine pituitaries using a hot glacial acetic acid extraction method and was partially purified by gel filtration. When injected intraventricularly in rats, these purified peptides induced strong analgesia, catelepsy, respiratory depression and other opiate-like effects, which lasted for several hours.

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