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. 1999 Feb;52(2):134-41.
doi: 10.7164/antibiotics.52.134.

(-)-Phenylahistin arrests cells in mitosis by inhibiting tubulin polymerization

K Kanoh  1 , S Kohno, J Katada, J Takahashi, I Uno
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Free article

(-)-Phenylahistin arrests cells in mitosis by inhibiting tubulin polymerization

K Kanoh et al. J Antibiot (Tokyo). 1999 Feb.
Free article

Abstract

(-)-Phenylahistin, a fungal diketopiperazine metabolite composed of phenylalanine and isoprenylated dehydrohistidine, arrested cells in mitosis and inhibited the proliferation of A549 cells. The microtubule network in A549 cells was disrupted by (-)-phenylahistin, which also inhibited the polymerization of both microtubule protein from bovine brain and phosphocellulose-purified tubulin in vitro. Competitive binding studies indicated that (-)-phenylahistin interacted with the colchicine binding site on tubulin but not with the vinblastine binding site.

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