doi: 10.7164/antibiotics.52.134.
(-)-Phenylahistin arrests cells in mitosis by inhibiting tubulin polymerization
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- PMID: 10344567
- DOI: 10.7164/antibiotics.52.134
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(-)-Phenylahistin arrests cells in mitosis by inhibiting tubulin polymerization
J Antibiot (Tokyo).
1999 Feb.
Free article
Abstract
(-)-Phenylahistin, a fungal diketopiperazine metabolite composed of phenylalanine and isoprenylated dehydrohistidine, arrested cells in mitosis and inhibited the proliferation of A549 cells. The microtubule network in A549 cells was disrupted by (-)-phenylahistin, which also inhibited the polymerization of both microtubule protein from bovine brain and phosphocellulose-purified tubulin in vitro. Competitive binding studies indicated that (-)-phenylahistin interacted with the colchicine binding site on tubulin but not with the vinblastine binding site.
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