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. 1999 Mar;52(3):256-62.
doi: 10.7164/antibiotics.52.256.

Novel naphthoquinones from a Streptomyces sp

P Kulanthaivel  1 , T J Perun Jr, M D Belvo, R J Strobel, D C Paul, D C Williams
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Free article

Novel naphthoquinones from a Streptomyces sp

P Kulanthaivel et al. J Antibiot (Tokyo). 1999 Mar.
Free article

Abstract

Cdc25A assay-guided fractionation of a fermentation broth derived from a Streptomyces sp. resulted in the isolation of four novel naphthoquinones 1-4. Structures of these compounds were deduced by NMR and mass spectrometry. Two of them, 3 and 4, incorporate a modified cysteine residue which is observed for the first time in this class of natural products. Naphthoquinones 1-4 showed weak activity against cdc25A phosphatase.

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