Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Jun;43(6):1465-8.
doi: 10.1128/AAC.43.6.1465.

Piperacillin and tazobactam exhibit linear pharmacokinetics after multiple standard clinical doses

B Auclair  1 , M P Ducharme
Affiliations

Piperacillin and tazobactam exhibit linear pharmacokinetics after multiple standard clinical doses

B Auclair et al. Antimicrob Agents Chemother. 1999 Jun.

Abstract

A population pharmacokinetic (PK) analysis was conducted to determine if piperacillin and tazobactam exhibited linear or nonlinear PKs and if incremental changes in the daily dosage of piperacillin affected tazobactam PKs. Four dosage groups were evaluated after multiple dosing regimens. Concentrations of drug in plasma and amounts in urine were best fitted by using a linear two-compartment PK model. No significant difference between dosing groups was seen for any piperacillin or tazobactam PK parameters. Both drugs exhibited linear PKs when given at usual clinical doses. Tazobactam PKs did not appear to be affected by the different dosing regimens of piperacillin.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Relationships between the mean estimated AUC/dose, the calculated individual CL, VSS, and elimination t1/2 versus the administered doses of piperacillin and tazobactam.
See this image and copyright information in PMC

References

    1. Akaike H. A Bayesian extension of the minimum AIC procedure of autoregressive model fitting. Biometrika. 1992;66:237–242.
    1. Aronoff G R, Sloan R S, Brier M E, Luft F C. The effect of piperacillin dose on elimination kinetics in renal impairment. Eur J Clin Pharmacol. 1983;24:543–547. - PubMed
    1. Batra V K, Morrison J A, Lasseter K C, Joy V A. Piperacillin kinetics. Clin Pharmacol Ther. 1979;26:41–53. - PubMed
    1. Bergan T, Williams J D. Dose dependence of piperacillin pharmacokinetics. Chemotherapy. 1982;28:153–159. - PubMed
    1. Collins D, Forrest A. IT2S user’s guide. Buffalo, N.Y: State University of New York at Buffalo; 1995.

Publication types

LinkOut - more resources