Piperacillin and tazobactam exhibit linear pharmacokinetics after multiple standard clinical doses

Abstract

A population pharmacokinetic (PK) analysis was conducted to determine if piperacillin and tazobactam exhibited linear or nonlinear PKs and if incremental changes in the daily dosage of piperacillin affected tazobactam PKs. Four dosage groups were evaluated after multiple dosing regimens. Concentrations of drug in plasma and amounts in urine were best fitted by using a linear two-compartment PK model. No significant difference between dosing groups was seen for any piperacillin or tazobactam PK parameters. Both drugs exhibited linear PKs when given at usual clinical doses. Tazobactam PKs did not appear to be affected by the different dosing regimens of piperacillin.

FIG. 1

Relationships between the mean estimated AUC/dose, the calculated individual CL, V_SS, and elimination t_1/2 versus the administered doses of piperacillin and tazobactam.