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. 1999 Jun;43(6):1480-3.
doi: 10.1128/AAC.43.6.1480.

Emergence in france of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin

C Doit  1 , C Loukil, F Fitoussi, P Geslin, E Bingen
Affiliations

Emergence in france of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin

C Doit et al. Antimicrob Agents Chemother. 1999 Jun.

Abstract

The genetic relatedness of French isolates of Streptococcus pneumoniae highly resistant to amoxicillin (MIC, >/=4 microg/ml, equal to or exceeding those of penicillin) was investigated by molecular fingerprinting. The results suggest that high-level resistance to amoxicillin has emerged within preexisting penicillin-resistant clones.

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Figures

FIG. 1
FIG. 1
Dendrogram depicting genetic distance and overall relatedness of pneumococcal isolates on the basis of rrn RFLP data. a, isolates for which cefotaxime MICs were ≥4 μg/ml. See Table 1 for the other characteristics of the isolates. (b, c, d, e, and f are representative of the serotype 9V/14 penicillin-resistant French clone, the serotype 6B penicillin-resistant Spanish clone, the serotype 6B penicillin-resistant French clone, the French derivatives of the pandemic 23F multiresistant Spanish clone, and the pandemic serotype 23F multiresistant Spanish clone, respectively.)
See this image and copyright information in PMC

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