Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Jun;43(6):1525-7.
doi: 10.1128/AAC.43.6.1525.

In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum

P Ringwald  1 , E C Eboumbou, J Bickii, L K Basco
Affiliations

In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum

P Ringwald et al. Antimicrob Agents Chemother. 1999 Jun.

Abstract

The in vitro activities of pyronaridine, alone and in combination with established antimalarial drugs, were assessed by isotopic microtest. Pyronaridine was highly active against all Cameroonian isolates. A positive correlation was observed between the response to pyronaridine and that to chloroquine. Drug combination studies showed synergy between pyronaridine and primaquine, additive effects with 4-aminoquinolines, and weak antagonism with dihydroartemisinin, antifolates, or amino alcohols.

PubMed Disclaimer

References

    1. Basco L K, Le Bras J. In vitro activity of pyronaridine against African strains of Plasmodium falciparum. Ann Trop Med Parasitol. 1992;86:447–454. - PubMed
    1. Berenbaum M C. A method for testing for synergy with any number of agents. J Infect Dis. 1978;137:122–130. - PubMed
    1. Canfield C J, Pudney M, Gutteridge W E. Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro. Exp Parasitol. 1995;80:373–381. - PubMed
    1. Chen C, Tang L H, Jantanavivat C. Studies on a new antimalarial compound: pyronaridine. Trans R Soc Trop Med Hyg. 1992;86:7–10. - PubMed
    1. Childs G E, Hausler B, Milhous W, Chen C, Wimonwattrawatee T, Pooyindee N, Boudreau E F. In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum. Am J Trop Med Hyg. 1988;38:24–29. - PubMed

Publication types

LinkOut - more resources