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Review
. 1999 Feb;25(1):38-45.
doi: 10.1006/bcmd.1999.0225.

Advantages of the CBA mouse in leukemogenesis research

K N Rithidech  1 , E P Cronkite, V P Bond
Affiliations
Review

Advantages of the CBA mouse in leukemogenesis research

K N Rithidech et al. Blood Cells Mol Dis. 1999 Feb.

Abstract

The objectives of this review are to: (a) demonstrate that the male CBA/Ca mouse has several characteristics that make it an excellent animal for the study of leukemogenesis, (b) show that several of the genetic abnormalities observed in the male CBA/Ca mouse during the development of radiation induced acute myeloid leukemia (AML) are syntenic with those frequently detected in patients with myeloid disorders such as myelodysplastic syndrome and AML, (c) illustrate that leukemia-related chromosomal lesions are the indicators for high risk individuals.

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