Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 May 31;145(5):923-6.
doi: 10.1083/jcb.145.5.923.

Molecular bases for the recognition of tyrosine-based sorting signals

J S Bonifacino  1 , E C Dell'Angelica
Affiliations
Review

Molecular bases for the recognition of tyrosine-based sorting signals

J S Bonifacino et al. J Cell Biol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A) Schematic representation of AP complexes. Each AP complex consists of two large subunits (γ/α/δ/ε and β1-4), one medium subunit (μ1-4), and one small subunit (σ1-4). Some subunits exist in more than one isoform. (B) Bipartite structure of μ2 (approximate residue numbers indicated in parentheses) and ribbon representation of its YXXØ-binding domain complexed to a DYQRLN peptide (adapted from reference ; PDB accession code 1BXX). (C) Residues of rat μ2 involved in interactions with YXXØ signals and corresponding residues in other members of the AP μ family. Y- and Ø-binding residues are indicated in red and blue, respectively.
See this image and copyright information in PMC

References

    1. Aguilar RC, Ohno H, Roche KC, Bonifacino JS. Functional domain mapping of the clathrin-associated adaptor medium chains μ1 and μ2. J Biol Chem. 1997;272:2760–2766. - PubMed
    1. Anderson RGW, Goldstein JL, Brown MS. A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts. Nature. 1977;270:695–699. - PubMed
    1. Arneson LS, Miller J. Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence. J Cell Biol. 1995;129:1217–1228. - PMC - PubMed
    1. Boll W, Ohno H, Songyang Z, Rapoport I, Cantley LC, Bonifacino JS, Kirchhausen T. Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes. EMBO (Eur Mol Biol Organ) J. 1996;15:5789–5795. - PMC - PubMed
    1. Canfield WM, Johnson KF, Ye RD, Gregory W, Kornfeld S. Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail. J Biol Chem. 1991;266:5682–5688. - PubMed