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Review
. 1999 May 31;145(5):927-32.
doi: 10.1083/jcb.145.5.927.

Heptahelical receptor signaling: beyond the G protein paradigm

R A Hall  1 , R T Premont, R J Lefkowitz
Affiliations
Review

Heptahelical receptor signaling: beyond the G protein paradigm

R A Hall et al. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
Schematic diagram of heptahelical receptor signaling. (A) The G protein paradigm. Following agonist binding, heptahelical receptors activate heterotrimeric G proteins (G), which then regulate the activity of specific cellular effectors. (B) Beyond the G protein paradigm. Following agonist binding, heptahelical receptors can associate with members of diverse families of intracellular proteins, including heterotrimeric G proteins (G), polyproline-binding proteins such as those containing SH3 domains (SH3), arrestins (Arr), G protein–coupled receptor kinases (GRK), small GTP-binding proteins (g), SH2 domain–containing proteins (SH2) and PDZ domain–containing proteins (PDZ). These interactions allow heptahelical receptors to initiate multiple intracellular signaling pathways, with each subtype of receptor likely coupled to a relatively unique set of effectors.
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