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Review
. 1999 Mar;37(3):293-7.
doi: 10.1515/CCLM.1999.051.

Regulation of leukocyte trafficking by lipoxins

P Diamond  1 , A McGinty, D Sugrue, H R Brady, C Godson
Affiliations
Review

Regulation of leukocyte trafficking by lipoxins

P Diamond et al. Clin Chem Lab Med. 1999 Mar.

Abstract

Lipoxins are lipoxygenase interaction products formed by transcellular metabolism during host defence and inflammation. In model systems, lipoxins modulate polymorphonuclear leukocytes (PMN) chemotaxis, adhesion molecule expression, inhibit PMN-endothelial cell adhesion, and attenuate cytokine release from epithelial cells. These observations raise the possibility that lipoxins are 'stop signals' for PMN-mediated tissue injury and promote the resolution of acute inflammation.

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