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. 1999 Jun;152(2):755-61.
doi: 10.1093/genetics/152.2.755.

Using maximum likelihood to estimate population size from temporal changes in allele frequencies

E G Williamson  1 , M Slatkin
Affiliations

Using maximum likelihood to estimate population size from temporal changes in allele frequencies

E G Williamson et al. Genetics. 1999 Jun.

Abstract

We develop a maximum-likelihood framework for using temporal changes in allele frequencies to estimate the number of breeding individuals in a population. We use simulations to compare the performance of this estimator to an F-statistic estimator of variance effective population size. The maximum-likelihood estimator had a lower variance and smaller bias. Taking advantage of the likelihood framework, we extend the model to include exponential growth and show that temporal allele frequency data from three or more sampling events can be used to test for population growth.

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