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Case Reports
. 1999 Jun;105(3):764-7.
doi: 10.1046/j.1365-2141.1999.01402.x.

Establishment of a near-triploid human B-cell lymphoma cell line with t(14;18) and a p53 gene point mutation

H Yamaguchi  1 , K Inokuchi, H Hanawa, S Tanosaki, I Shinozawa, H Matuoka, K Dan
Affiliations
Case Reports

Establishment of a near-triploid human B-cell lymphoma cell line with t(14;18) and a p53 gene point mutation

H Yamaguchi et al. Br J Haematol. 1999 Jun.

Abstract

We report a rare large B-cell non-Hodgkin's lymphoma having a characteristic near-triploid cell population with add(17)(p22) and t(14;18)(q32;q21) translocation. We also established and characterized a new cell line (TK cell) derived from the present lymphoma. A codon 180 mutation (GAG --> GAT) in the p53 gene was detected. t(14;18)(q32;q21) was revealed juxtaposition of the bcl-2 and JH genes. Immunoprecipitation analyses of p53 and bcl-2 revealed that abnormality of the p53 protein and aberrant bcl-2 expression, which may protect cells from apoptosis, may be critical to the development of leukaemogenesis exhibiting near-triploid chromosomes.

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