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. 1999 May;7(5):191-5.
doi: 10.1016/s0966-842x(99)01493-6.

Pathoadaptive mutations: gene loss and variation in bacterial pathogens

E V Sokurenko  1 , D L Hasty, D E Dykhuizen
Affiliations

Pathoadaptive mutations: gene loss and variation in bacterial pathogens

E V Sokurenko et al. Trends Microbiol. 1999 May.

Abstract

Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species.

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