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Review
. 1999 May;20(5):205-10.
doi: 10.1016/s0165-6147(99)01310-3.

The interactions of adenylate cyclases with P-site inhibitors

C W Dessauer  1 , J J Tesmer, S R Sprang, A G Gilman
Affiliations
Review

The interactions of adenylate cyclases with P-site inhibitors

C W Dessauer et al. Trends Pharmacol Sci. 1999 May.

Abstract

Recent kinetic, binding and crystallographic studies using P-site inhibitors of mammalian adenylate bases provide new insights into the catalytic mechanism of these highly regulated enzymes. Here, Carmen Dessauer and colleagues discuss the conformational states of adenylate cyclase, the structural determinants of inhibitor binding and the potential uses of these inhibitors as pharmacological agents.

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