Review
doi: 10.1016/s0079-6107(98)00049-2.
The role of SHIP in growth factor induced signalling
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- PMID: 10354708
- DOI: 10.1016/s0079-6107(98)00049-2
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Review
The role of SHIP in growth factor induced signalling
Prog Biophys Mol Biol.
1999.
Free article
Abstract
The recently cloned, hemopoietic-specific, src homology 2 (SH2)-containing inositol phosphatase, SHIP, is rapidly gaining prominence as a potential regulator of all phosphatidylinositol (PI)-3 kinase mediated events since it has been shown both in vitro and in vivo to hydrolyze the 5' phosphate from phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3). Thus SHIP, and its more widely expressed counterpart, SHIP2, could play a central role in determining PI-3,4,5-P3 and PI-3,4-P2 levels in many cell types. To explore the in vivo function of SHIP further we recently generated a SHIP knock out mouse and in this review we discuss experiments carried out with bone marrow derived mast cells (BMMCs) from these animals.
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