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. 1999 May 17;9(10):1385-90.
doi: 10.1016/s0960-894x(99)00192-4.

Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin

E Osz  1 , L Somsák, L Szilágyi, L Kovács, T Docsa, B Tóth, P Gergely
Affiliations

Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin

E Osz et al. Bioorg Med Chem Lett. .

Abstract

Reaction of C-(1-bromo-1-deoxy-beta-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of D-glucopyanosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases.

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