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. 1999 May 17;9(10):1429-32.
doi: 10.1016/s0960-894x(99)00211-5.

Uncarinic acids: phospholipase Cgamma1 inhibitors from hooks of Uncaria rhynchophylla

J S Lee  1 , M Y Yang, H Yeo, J Kim, H S Lee, J S Ahn
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Uncarinic acids: phospholipase Cgamma1 inhibitors from hooks of Uncaria rhynchophylla

J S Lee et al. Bioorg Med Chem Lett. .

Abstract

Bioactivity-guided fractionation of the CHCl3 extract from hooks of Uncaria rhynchophylla led to the isolation of two triterpene esters, namely uncarinic acids A (1) and B (2). Their structures were established by spectroscopic and chemical methods. These compounds inhibited phospholipase Cgamma1 with IC50 values of 35.66 and 44.55 microM, respectively.

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