Genetic studies of the offspring of identical twins: a model for the analysis of quantitative inheritance in man

Abstract

In conjunction with full-sib and parental observations, half-sib analysis permits an estimation of the genetic and environmental variance as well as a partitioning of the genetic variance into its additive, dominance and epistatic components. The offspring of identical twins are a unique class of human half-sibs who provide an unusual opportunity to resolve and measure several additional potentially important sources of human variation including maternal effects, the influences of common environmental factors and assortative mating. The genetic model thus developed for the analysis of quantitative inheritance in man has been applied to the analysis of total ridge count and birth weight, confirming the existence of a major additive genetic effect on ridge count and a significant maternal effect on birth weight.