Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1999 Apr;90(4):367-71.
doi: 10.1111/j.1349-7006.1999.tb00756.x.

Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: a pilot study

K Tanaka  1 , M Ikeda, A Nozaki, N Kato, H Tsuda, S Saito, H Sekihara
Affiliations
Clinical Trial

Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: a pilot study

K Tanaka et al. Jpn J Cancer Res. 1999 Apr.

Abstract

Hepatitis C virus (HCV) is associated with the development of cirrhosis and hepatocellular carcinoma. We recently found that bovine lactoferrin, a milk protein belonging to the iron transporter family, effectively prevented HCV infection in cultured human hepatocytes (PH5CH8). We tested the hypothesis that lactoferrin inhibits HCV viremia in patients with chronic hepatitis C. Eleven patients with chronic hepatitis C received an 8-week course of bovine lactoferrin (1.8 or 3.6 g/day). At the end of lactoferrin treatment, a decrease in serum alanine transaminase and HCV RNA concentrations was apparent in 3 (75%) of 4 patients with low pretreatment serum concentrations of HCV RNA. However, 7 patients with high pretreatment concentrations showed no significant changes in these indices. This pilot study suggests that lactoferrin is one potential candidate as an anti-HCV reagent that may be effective for the treatment of patients with chronic hepatitis.

PubMed Disclaimer

References

    1. Choo , Q. L. , Kuo , G. , Weiner , A. J. , Overby , L. R. , Bradley , D. W. and Houghton , M.Isolation of a cDNA clone derived from a blood‐borne non‐A, non‐B viral hepatitis genome . Science , 244 , 359 – 362 ( 1989. ). - PubMed
    1. Kuo , G. , Choo , Q. L. , Alter , H. J. , Gitnick , G. L. , Redwker , A. G. , Purcell , R. H. , Miyamura , T. , Dienstag , J. L. , Alter , M. J. , Stevens , C. E. , Tegtmeieer , G. E. , Bonino , F. , Colombo , W. S. , Lee , W. S. , Kuo , C. , Berger , K. , Shuster , J. R. , Overby , L. R. , Bradley , D. W. and Houghton , M.An assay for circulating antibodies to a major etiologic virus of human non‐A, non‐B hepatitis . Science , 244 , 362 – 364 ( 1989. ). - PubMed
    1. Ohkoshi , S. , Kojima , H. , Tawaraya , H. , Miyajima , T. , Kamimura , T. , Asakura , H. , Satoh , A. , Hirose , S. , Hijikata , M. , Kato , N. and Shimotohno , K.Prevalence of antibody against non‐A, non‐B hepatitis virus in Japanese patients with hepatocellular carcinoma . Jpn. J. Cancer Res. , 81 , 550 – 553 ( 1990. ). - PMC - PubMed
    1. Saito , I. , Miyamura , T. , Ohbayashi , A. , Harada , H. , Katayama , T. , Kikuchi , S. , Watanabe , Y. , Koi , S. , Onji , M. , Ohta , Y. , Choo , Q. L. , Houghton , M. and Kuo , G.Hepatitis C virus infection is associated with the development of hepatocellular carcinoma . Proc. Natl. Acad. Sci. USA , 87 , 6547 – 6549 ( 1990. ). - PMC - PubMed
    1. Hoofnagle , J. H. , Mullen , K. D. , Jones , D. B. , Rustgi , V. , di Bisceglie , A. , Peters , M. , Waggoner , J. G. , Park , Y. and Jones , E. A.Treatment of chronic non‐A, non‐B hepatitis with recombinant human alpha interferon: a preliminary report . N. Engl. J. Med. , 315 , 1575 – 1578 ( 1986. ). - PubMed

Publication types

LinkOut - more resources