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Multicenter Study
. 1999 Jun 12;318(7198):1591-4.
doi: 10.1136/bmj.318.7198.1591.

Risk factors for erysipelas of the leg (cellulitis): case-control study

A Dupuy  1 , H Benchikhi, J C Roujeau, P Bernard, L Vaillant, O Chosidow, B Sassolas, J C Guillaume, J J Grob, S Bastuji-Garin
Affiliations
Multicenter Study

Risk factors for erysipelas of the leg (cellulitis): case-control study

A Dupuy et al. BMJ. .

Abstract

Objective: To assess risk factors for erysipelas of the leg (cellulitis).

Design: Case-control study.

Setting: 7 hospital centres in France.

Subjects: 167 patients admitted to hospital for erysipelas of the leg and 294 controls.

Results: In multivariate analysis, a disruption of the cutaneous barrier (leg ulcer, wound, fissurated toe-web intertrigo, pressure ulcer, or leg dermatosis) (odds ratio 23.8, 95% confidence interval 10.7 to 52.5), lymphoedema (71.2, 5.6 to 908), venous insufficiency (2.9, 1.0 to 8.7), leg oedema (2.5, 1.2 to 5.1) and being overweight (2.0, 1.1 to 3.7) were independently associated with erysipelas of the leg. No association was observed with diabetes, alcohol, or smoking. Population attributable risk for toe-web intertrigo was 61%.

Conclusion: This first case-control study highlights the major role of local risk factors (mainly lymphoedema and site of entry) in erysipelas of the leg. From a public health perspective, detecting and treating toe-web intertrigo should be evaluated in the secondary prevention of erysipelas of the leg.

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References

    1. Bisno AL, Stevens DL. Streptococcal infections of skin and soft tissues. N Engl J Med. 1996;334:240–245. - PubMed
    1. Bernard P. Dermo-hypodermal bacterial infections. Current concepts. Eur J Med. 1992;1:97–104. - PubMed
    1. Bernard P, Bedane C, Mounier M, Denis F, Catanzano G, Bonnetblanc JM. Streptococcal cause of erysipelas and cellulitis in adults. A microbiologic study using a direct immunofluorescence technique. Arch Dermatol. 1989;125:779–782. - PubMed
    1. Crickx B, Chevron F, Sigal-Nahum M, Bilet S, Faucher F, Picard C, et al. Erysipèle: Données épidémiologiques, cliniques et thérapeutiques. Ann Dermatol Venereol. 1991;118:11–16. - PubMed
    1. Ronnen M, Suster S, Schewach-Millet M, Modan M. Erysipelas: changing faces. Int J Dermatol. 1985;24:169–172. - PubMed

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