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Case Reports
. 1976 Oct;38(4):1476-8.
doi: 10.1002/1097-0142(197610)38:4<1476::aid-cncr2820380405>3.0.co;2-j.

Successful therapy with methotrexate of a multicentric mixed lymphoma of the central nervous system

K D Herbst, M P Corder, G R Justice
Case Reports

Successful therapy with methotrexate of a multicentric mixed lymphoma of the central nervous system

K D Herbst et al. Cancer. 1976 Oct.

Abstract

Primary lymphoma of the central nervous system (CNS) is extremely rare. A case of mixed histiocytic lymphocytic lymphoma of the CNS that initially occurred in the spinal cord is reported. Multicentric recurrence following radiotherapy was successfully treated with intrathecal methotrexate and the patient remains free of disease after 4 years. The role of intrathecal methotrexate as alternative therapy following irradiation failure is discussed.

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