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. 1999 Mar-Apr;19(2A):1229-34.

Synthesis and cytotoxicity of aminosterols: activity studies on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6)

L el Kihel  1 , S Bosch, M Dherbomez, C Roussakis, Y Letourneux
Affiliations
  • PMID: 10368680

Synthesis and cytotoxicity of aminosterols: activity studies on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6)

L el Kihel et al. Anticancer Res. 1999 Mar-Apr.

Abstract

Various new aminosterols were synthesized. The antiproliferative activity of these compounds (I-IV) was studied in vitro on a continuous human non small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. The histograms indicate cell blockage in Phase Gl (compound I-III) associated with a reduction in the number of cells phases S and G2M and appearance of cellular debris derived from cells in Phase G1.

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