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Clinical Trial
. 1999 Jun;5(6):651-5.
doi: 10.1038/9498.

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

T W Chun  1 , D Engel, S B Mizell, C W Hallahan, M Fischette, S Park, R T Davey Jr, M Dybul, J A Kovacs, J A Metcalf, J M Mican, M M Berrey, L Corey, H C Lane, A S Fauci
Affiliations
Clinical Trial

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

T W Chun et al. Nat Med. 1999 Jun.

Abstract

The size of the pool of resting CD4+ T cells containing replication-competent HIV in the blood of patients receiving intermittent interleukin (IL)-2 plus highly active anti-retroviral therapy (HAART) was significantly lower than that of patients receiving HAART alone. Virus could not be isolated from the peripheral blood CD4+ T cells in three patients receiving IL-2 plus HAART, despite the fact that large numbers of resting CD4+ T cells were cultured. Lymph node biopsies were done in two of these three patients and virus could not be isolated. These results indicate that the intermittent administration of IL-2 with continuous HAART may lead to a substantial reduction in the pool of resting CD4+ T cells that contain replication-competent HIV.

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