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Review
. 1999 Jun 5;353(9168):1959-64.
doi: 10.1016/S0140-6736(99)01307-0.

Neuropathic pain: aetiology, symptoms, mechanisms, and management

C J Woolf  1 , R J Mannion
Affiliations
Review

Neuropathic pain: aetiology, symptoms, mechanisms, and management

C J Woolf et al. Lancet. .

Abstract

We highlight current theories about peripheral neuropathic pain and show that progress in management is contingent on targeting treatment not at the aetiological factors or the symptoms but at the mechanisms that operate to produce the symptoms. This approach will require substantial progress in our understanding of the pathophysiology of neuropathic pain, the development of accurate diagnostic tools to discover what mechanisms contribute to the pain syndrome in an individual, and effective treatments aimed specifically at the mechanisms.

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Comment in

  • Neuropathic pain.
    Marples IL, Murray P. Marples IL, et al. Lancet. 1999 Sep 11;354(9182):953-4. doi: 10.1016/S0140-6736(05)75704-4. Lancet. 1999. PMID: 10489984 No abstract available.

MeSH terms