Effect of ethyl apovincaminate on cerebral, cardiac and renal flow rate in dogs in the course of administration
- PMID: 1037214
Item in Clipboard
Effect of ethyl apovincaminate on cerebral, cardiac and renal flow rate in dogs in the course of administration
Arzneimittelforschung.
1976.
Abstract
Cerebral, myocardial and renal capillary flow rate was significantly increased by 10 to 20 mug/kg/min doses of ethyl apovincaminate (RGH-4405, Cavinton) injected in slow infusion to dogs. These effects were long-lasting. Since perfusion pressure and heart rate were not affected by the compound, it was concluded that increased flow rate was attributable to decrease of peripheral vascular resistance. Results indicate that Cavinton has a vasodilatory effect.
Similar articles
-
General and cerebral haemodynamic activity of ethyl apovincaminate.Arzneimittelforschung. 1976;26(10a):1908-12. Arzneimittelforschung. 1976. PMID: 1037212
-
Effect of oral pretreatment with ethyl apovincaminate on the cardiac output and nutritive blood flow of various organs in rats.Arzneimittelforschung. 1976;26(10a):1912. Arzneimittelforschung. 1976. PMID: 1037213
-
Effect of ethyl apovincaminate on the cerebral circulation. Studies in patients with obliterative cerebral arterial disease.Arzneimittelforschung. 1976;26(10a):1945-7. Arzneimittelforschung. 1976. PMID: 1037221
-
Effect of ethyl apovincaminate on cerebral circulation of dogs under normal conditions and in arterial hypoxia.Arzneimittelforschung. 1976;26(10a):1920-3. Arzneimittelforschung. 1976. PMID: 1037216
-
Hemodynamic profile of a new cerebral vasodilator, vincamine and of one of its derivatives, apovincaminic acid ethylester (RGH-4405).Arch Int Pharmacodyn Ther. 1977 Mar;226(1):139-48. Arch Int Pharmacodyn Ther. 1977. PMID: 869636
Cited by
-
Psychopharmacological effects of vinpocetine in normal healthy volunteers.Eur J Clin Pharmacol. 1985;28(5):567-71. doi: 10.1007/BF00544068. Eur J Clin Pharmacol. 1985. PMID: 3899677 Clinical Trial.