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. 1978 Dec 1;52(3-4):401-3.
doi: 10.1016/0014-2999(78)90298-4.

Histamine-induced release of thyrotropin releasing hormone from hypothalamic slices

J L Charli, P Joseph-Bravo, J M Palacios, C Kordon

Histamine-induced release of thyrotropin releasing hormone from hypothalamic slices

J L Charli et al. Eur J Pharmacol. .

Abstract

In vitro release of TRH from mediobasal hypothalamic (MBH) slices was increased in the presence of 56 mM K+ in a Ca2+-dependent manner. Addition of histamine (HA) induced a concentration-dependent release of TRH; concentrations of 3 x 10(-7) M and 10(-6) M elicited maximal and maximal stimulation respectively. Cimetidine 10(-6) M, a potent antagonist of HA H2-receptors, inhibited the effect of HA. The present results suggest that HA can trigger the release of TRH from neurosecretory nerve endings and that MBH slices are a useful preparation for studying neurohormone release.

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