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Review
. 1999 Jun;11(3):294-300.
doi: 10.1016/s0952-7915(99)80047-8.

CTLA-4 and T cell activation

M A Oosterwegel  1 , R J Greenwald, D A Mandelbrot, R B Lorsbach, A H Sharpe
Affiliations
Review

CTLA-4 and T cell activation

M A Oosterwegel et al. Curr Opin Immunol. 1999 Jun.

Abstract

The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work has also revealed a role for CTLA-4 in regulating Th1/Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases.

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