Review
doi: 10.1016/s0952-7915(99)80047-8.
CTLA-4 and T cell activation
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- PMID: 10375557
- DOI: 10.1016/s0952-7915(99)80047-8
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Review
CTLA-4 and T cell activation
Curr Opin Immunol.
1999 Jun.
Abstract
The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work has also revealed a role for CTLA-4 in regulating Th1/Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases.
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