Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Sep;19(5):437-9.

Pharmacokinetics of theophylline metabolites in 8 Chinese patients

W Cao  1 , H T Zhuo, G Chen, S S Ling
Affiliations
  • PMID: 10375804
Free article

Pharmacokinetics of theophylline metabolites in 8 Chinese patients

W Cao et al. Zhongguo Yao Li Xue Bao. 1998 Sep.
Free article

Abstract

Aim: To study theophylline metabolites pharmacokinetics in patients after a therapeutic dose.

Methods: Eight adult patients with mild bronchial asthma and normal liver function were infused aminophylline intravenously (6.6 mumol.kg-1). The plasma concentrations of theophylline and its 4 metabolites: 1,3-dimethyluric acid (DMUA), 3-methylxanthine (3-MX), 1-methyluric acid (MUA), and the intermediate 1-methylxanthine (1-MX) were monitored by HPLC throughout 24 h.

Results: The plasma concentration of DMUA was the highest one among the 4 metabolites. 3-MX showed the slowest elimination rate. The plasma concentration of 1-MX throughout a 24-h period showed that there was a picking up of 1-MX (from 0.04 mumol.L-1 to 1.05 mumol.L-1) in the next morning.

Conclusion: The formation of DMUA was the main metabolites. During night there was an accumulation of 1-MX.

PubMed Disclaimer

Publication types