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Review
. 1999 Jun 4;452(1-2):47-51.
doi: 10.1016/s0014-5793(99)00528-1.

Transfer RNA modification: influence on translational frameshifting and metabolism

G R Björk  1 , J M Durand, T G Hagervall, R Leipuviene, H K Lundgren, K Nilsson, P Chen, Q Qian, J Urbonavicius
Affiliations
Free article
Review

Transfer RNA modification: influence on translational frameshifting and metabolism

G R Björk et al. FEBS Lett. .
Free article

Abstract

Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471-482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed.

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