Review
doi: 10.1016/s0014-5793(99)00543-8.
Lipid signaling in CD95-mediated apoptosis
Affiliations
- PMID: 10376687
- DOI: 10.1016/s0014-5793(99)00543-8
Item in Clipboard
Review
Lipid signaling in CD95-mediated apoptosis
FEBS Lett.
.
Free article
Abstract
Ceramides play an important role mediating different cell responses such as proliferation, differentiation, growth arrest and apoptosis. They are released upon sphingomyelin hydrolysis which occurs after triggering of a number of cell surface receptors including CD95. Ceramide generation also regulates glycosphingolipid and ganglioside metabolism. In particular, ganglioside GD3 biosynthesis represents an important event for the progression of apoptotic signals generated by CD95 and mediated by ceramide in hematopoietic cells.
Similar articles
-
Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.Science. 1997 Sep 12;277(5332):1652-5. doi: 10.1126/science.277.5332.1652. Science. 1997. PMID: 9287216
-
Lipid and glycolipid mediators in CD95-induced apoptotic signaling.Results Probl Cell Differ. 1999;23:65-76. doi: 10.1007/978-3-540-69184-6_4. Results Probl Cell Differ. 1999. PMID: 9950029 Review. No abstract available.
-
Lipid signaling in CD95-mediated apoptosis.Subcell Biochem. 2002;36:285-308. doi: 10.1007/0-306-47931-1_15. Subcell Biochem. 2002. PMID: 12037987 Review. No abstract available.
-
Apoptotic signal of Fas is not mediated by ceramide.Blood. 1998 Apr 15;91(8):2658-63. Blood. 1998. PMID: 9531573
-
Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes.Proc Natl Acad Sci U S A. 1998 May 26;95(11):6169-74. doi: 10.1073/pnas.95.11.6169. Proc Natl Acad Sci U S A. 1998. PMID: 9600936 Free PMC article.
Cited by
-
The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells.Cell Cycle. 2012 Mar 1;11(5):1040-8. doi: 10.4161/cc.11.5.19520. Epub 2012 Mar 1. Cell Cycle. 2012. PMID: 22333579 Free PMC article.
-
Influence of gangliosides on the IL-2- and IL-4-dependent cell proliferation.Neurochem Res. 2002 Aug;27(7-8):761-70. doi: 10.1023/a:1020248722282. Neurochem Res. 2002. PMID: 12374211
-
Intracranial V. cholerae sialidase protects against excitotoxic neurodegeneration.PLoS One. 2011;6(12):e29285. doi: 10.1371/journal.pone.0029285. Epub 2011 Dec 15. PLoS One. 2011. PMID: 22195039 Free PMC article.
-
Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons.J Neurosci. 2002 May 15;22(10):3963-8. doi: 10.1523/JNEUROSCI.22-10-03963.2002. J Neurosci. 2002. PMID: 12019315 Free PMC article.
-
Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis.Transl Oncogenomics. 2008 Apr 10;3:81-98. Transl Oncogenomics. 2008. PMID: 21566746 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
