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. 1999 Jun;80(8):1262-4.
doi: 10.1038/sj.bjc.6690495.

Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients

J M Silva  1 , G Dominguez, M J Villanueva, R Gonzalez, J M Garcia, C Corbacho, M Provencio, P España, F Bonilla
Affiliations
Free PMC article

Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients

J M Silva et al. Br J Cancer. 1999 Jun.
Free PMC article

Abstract

Hypermethylation of exon 1 of p16INK4a was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16INK4a can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients.

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