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. 1999 May;8(2):161-70.
doi: 10.1046/j.1365-2583.1999.820161.x.

Voltage-gated sodium channel genes hscp and hDSC1 of Heliothis virescens F. genomic organization

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Voltage-gated sodium channel genes hscp and hDSC1 of Heliothis virescens F. genomic organization

Y Park et al. Insect Mol Biol. 1999 May.

Abstract

We report the genomic sequence of hscp, a sodium channel alpha subunit gene for Heliothis virescens. A 32-kb genomic clone and six independent RT-PCR products covering almost the entire coding region of the gene, contained thirty-one deduced exons with a translation of 1695 residues. Overall amino acid similarity to the para locus of Drosophila melanogaster was 86%. The transcription of the gene was complex. Alternate splicing was evident for five optional exons and a pair of mutually exclusive exons. A number of alternatively spliced mRNA revealed a deduced translation product that included only the first homology domain. We also report the first partial sequence for hDSC1, a presumed orthologous of the DSC1 sodium channel alpha subunit gene of D. melanogaster.

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