Muscle sympathetic nerve response to vestibular stimulation by sinusoidal linear acceleration in humans

Abstract

To clarify the effects of natural otolith stimulation on muscle sympathetic nerve activity (MSNA) in humans, eight male volunteers were seated in a linear accelerator (sled) during the recording of MSNA from the tibial nerve with microneurography, and also the recording of electrocardiogram, blood pressure measured with a Finapres device and thoracic impedance during movement. Sinusoidal linear acceleration with peak values of +/-0.10, 0.15 and 0.20 Gx were applied to the sitting subjects in the anteroposterior direction. Both the total activity and the burst rate of MSNA decreased during the sinusoidal linear acceleration, whereas the average heart rate, thoracic impedance and mean arterial pressure did not change significantly. These results suggest that moderate sinusoidal linear acceleration in the anteroposterior direction may suppress MSNA in humans.